" class="no-js "lang="en-US"> Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern - Medtech Alert
Friday, March 29, 2024

Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern

Results from the Canadian Immunization Research Network (CIRN) with support from Public Health Agency of Canada and the Canadian Institutes of Health Research, published as a pre-print, demonstrated one dose of Vaxzevria was 82% effective against hospitalisation or death caused by the Beta/Gamma variants of the SARS-CoV-2 virus. The vaccine also showed a high level of effectiveness against the Delta (B.617.2, ‘Indian’) and Alpha (B.1.1.7, ‘Kent’) variants with an 87% and 90% reduction of hospitalisations or deaths respectively. The effectiveness of Vaxzevria after one dose against hospitalisation or death was similar to that of other vaccines tested in the study. Follow-up time was not sufficient to report on effectiveness of Vaxzevria after two doses, other studies have shown an increased effectiveness following the indicated two dose schedule.

Vaxzevria was effective against milder symptomatic disease although, given that data was only reported after a first dose instead of the indicated two dose schedule where efficacy is known to be enhanced in this disease setting, the efficacy was lower than against severe disease. Vaccine effectiveness against any symptomatic disease was 50% against the Beta/Gamma variants, and 70% and 72% against the Delta and Alpha variants, respectively.

A Phase I/II trial carried out by the University of Oxford and University of the Witwatersrand in January, had shown limited efficacy against mild disease primarily due to the Beta variant. It was unable to properly ascertain vaccine efficacy against severe disease including  hospitalisation and death given that subjects were predominantly young, healthy adults who experienced mild disease only.

Mene Pangalos, Executive Vice President, BioPharmaceuticals R&D, said: “With different variants threatening to disrupt our route out of the pandemic, this real-world evidence shows that Vaxzevria, along with other vaccines used in Canada, provides a high level of protection against the most serious forms of the disease, even after just one shot. It is essential that we continue to protect as many people as possible in all corners of the world in order to get ahead of this deadly virus.”

The analysis included 69,533 individuals who tested positive for SARS-CoV-2 during December 2020 to May 2021 in Ontario, Canada; with 28,705 (6.8%) positive for non-variants of concern SARS-CoV-2 and 40,828 (9.7%) positive for a variant of concern.

People In This Post

Companies In This Post

  1. Eloxx Pharmaceuticals Announces Final Data Assessment from Phase 2 Combination Clinical Trial of ELX-02 in Class 1 Cystic Fibrosis Patients Read more
  2. Verge Genomics Announces Positive Safety and Tolerability Data from the Phase 1 Clinical Trial of VRG50635, a Potential Best-in-Class Therapeutic for All Forms of ALS Read more
  3. DEM BioPharma Appoints Wendy Young, Ph.D., to Scientific Advisory Board Read more
  4. Confo Therapeutics Enters into Research Collaboration for GPCR-Targeting Antibody Discovery with AbCellera Read more
  5. Vyriad Announces Expansion of T-Cell Lymphoma Trial at Mayo Clinic Read more