About Geltrude Mingrone

Geltrude Mingrone is Professor of Diabetes and Nutrition. She has a first class degree (magna cum laude) in Medicine and Surgery and two postgraduate degrees (magna cum laude) in Endocrinology and in Gastroenterology.

Her major scientific interest resides in the understanding of the mechanisms of prompt resolution of type 2 diabetes and insulin resistance after upper gut bypass in subjects with obesity. She studies how insulin sensitivity – measured with the euglycaemic hyperinsulinemic clamp and stable isotope infusion or with the hyperglycaemic clamp to compute also insulin secretion – modifies following bariatric surgery in subjects with obesity and various states of glucose tolerance, from normal glucose tolerance to impaired glucose tolerance, and to frank diabetes. She also investigates the pathophysiology of non-alcoholic fatty liver disease (NASH) and non-alcoholic steato-hepatitis (NASH) in rodents and in humans after diet manipulations as well as after bariatric surgery.

Recently, she took part in the international team, including 5 scientists from the European Union and 5 scientists from the United States, which issued the EASD/ADA conjunct guidelines for the treatment of type 2 diabetes.

Techniques used are euglycaemic hyperinsulinemic clamp, hyperglycaemic clamp, intravenous glucose tolerance test, hypoglycemic clamp, indirect calorimetry, body composition. Her team benefits of the valuable contribution of trained biologists and technicians, who study the insulin signalling in human and rodent biopsies as quell as in primary culture cells. Statisticians and mathematicians elaborate the experimental results calculating insulin sensitivity and insulin secretion by using sophisticate mathematical models.