" class="no-js "lang="en-US"> Shattuck Labs to Present Data in Ovarian Cancer Clinical Trial
Friday, June 09, 2023

Shattuck Labs to Present Complete Dose-Escalation Data from Phase 1A Monotherapy Clinical Trial of SL-172154 in Platinum-Resistant Ovarian Cancer

Shattuck Labs, a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, today announced the presentation of complete dose-escalation data from the Phase 1A monotherapy clinical trial of SL-172154 in PROC. These data will be featured in a poster presentation at the ASCO Annual Meeting, being held both virtually and in Chicago, IL from June 2-6, 2023.

“We are excited to present data at ASCO that we believe positions SL-172154 as a differentiated CD47 inhibitor and further underscores its therapeutic potential in heavily pretreated PROC patients,” said Dr. Lini Pandite, MBChB, M.B.A., Chief Medical Officer of Shattuck. “We believe SL-172154, a dual CD47 inhibitor and CD40 agonist, has a differentiated safety and pharmacodynamic profile and its hexameric structure enables CD40 activation in a fundamentally different manner than prior CD40 agonist therapies studied in humans. Preliminary analysis of pre- and on-treatment tumor biopsies further validates its mechanism of action.”

Dr. Pandite continued, “In the Phase 1A dose-escalation trial, SL-172154 had maximal CD47 and CD40 target engagement and CD40-dependent pharmacodynamic effects observed at the 3 mg/kg dose. SL-172154 had a favorable safety and tolerability profile across doses. Based on these encouraging data, we believe we have selected the optimal dose with maximal pharmacodynamic activity, which further supports our SL-172154 dose-expansion strategy in combination trials for patients with PROC. Our ongoing clinical trial of SL-172154 in combination with liposomal doxorubicin remains on track, and we expect to share initial data midyear. Additionally, we expect to share initial data from our clinical trial of SL-172154 in combination with mirvetuximab soravtansine in the second half of 2023.”

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