Promontory Therapeutics Announces Preliminary Data from the National Cancer Institute Phase 2 Clinical Trial of PT-112 in Thymoma and Thymic Carcinoma at 2023 ASCO Annual Meeting

Promontory Therapeutics, a clinical-stage pharmaceutical company advancing small molecule immunotherapies in oncology, announces preliminary data from a Phase 2 clinical trial of the company’s lead therapeutic candidate, PT-112, in patients with recurrent thymic epithelial tumors (TETs), specifically thymoma and thymic carcinoma. The trial is being conducted under formal collaboration with the National Cancer Institute (NCI), part of the National Institutes of Health (see NCT05104736). The data were published online in an abstract for the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting.

“Based on preliminary data to date, PT-112 appears to be safe and tolerable, and clinically active in patients with recurrent TETs. The initial translational evidence of PT-112 immune activation is encouraging and supportive of further investigation,” said Promontory Therapeutics Chief Medical Officer Johan Baeck, MD. “We are excited to provide a potential treatment option for patients with relapsed TETs, and are thrilled to continue our collaboration with the NCI.”

The Phase 2 clinical trial with the NCI is designed to assess the safety, tolerability, and clinical activity of PT-112 in patients with thymoma and thymic carcinoma, and to explore PT-112’s ability to promote immune activation and immune cell infiltration in response to treatment, via the extensive immuno-profiling capabilities of the NCI.

Promontory is providing NCI with PT-112 drug supply and support for correlative research, and NCI is overseeing enrollment and treatment of the clinical trial’s intended 53 patients.